You cannot use both the digi001 and the motu2408 at the same time. For one thing, they're incompatible. They both do essentially the same thing, which is bringing music in and out of the computer. Each one has it's own proprietary software. In the case of the Digi001, of course,it's ProTools LE. The Motu uses Digital Performer, for Mac's only. On a PC, you can use any software you like. In this respect, the 2408 is more versatile. A big plus in favor of the 2408, is that it has many more I/O choices. You can plug all 3 DA38's into the 2408's 3 TDIF interfaces, and use the 3 ADAT I/O to hook up to your DA7. The digi001 isn't going to be that kind. It has no TDIF interfaces, and only 8 channels of ADAT litepipe. Hope this explains why you can't use both systems together.